DMEM (Dulbecco’s Modified Eagle’s Medium) – High Glucose
DMEM is a widely used nutrient-rich cell culture medium in biological and biomedical research. This high-glucose formulation contains 4.5 g/L glucose, compared to 1 g/L in low-glucose versions, making it ideal for energy-demanding cells such as cancer cells, stem cells, and rapidly proliferating cell types.
Key Features & Usage
Cell Culture: Supports the growth of various mammalian cells, including fibroblasts, HeLa cells, and primary cell lines.
Research Applications: Used in studies on cell proliferation, differentiation, metabolism, and response to experimental treatments.
Stem Cell Culture: Preferred for culturing induced pluripotent stem cells (iPSCs) and other stem cells due to its nutrient-dense composition.
Supplementation & Handling
Fetal Bovine Serum (FBS): Typically added at 5–10% to provide essential growth factors, hormones, and nutrients.
Additional Supplements: Depending on cell line requirements, may include:
Antibiotics (e.g., penicillin-streptomycin)
Non-essential amino acids (NEAA)
Specialized growth factors
L-Glutamine Note: If the medium contains L-glutamine, monitor its stability and replenish as needed, as it degrades over time.
Sterile Technique: Essential during preparation and handling to prevent contamination.
Storage & Stability
Store at 2–8°C to maintain medium integrity.
Regularly check expiration dates and supplement stability (especially for labile components like L-glutamine).